Katherine Hepburn as “a flutter brained victim with love in her heart” in the 1938 film Bringing Up Baby.
Jean Seberg in Jean-Luc Godard’s 1960 New Wave classic, Breathless.
Shirley MacLaine as a prostitute in love with a policeman in Irma la Douce, 1963.
Sandy Dennis as a free-spirited "therapist" in the 1968 film Sweet November. The role was reprised by Charlize Theron in the 2001 remake.
Ruth Gordon in the 1971 cult classic Harold and Maude was not exactly a girl, but she was certainly unattainable.
Goldie Hawn in Butterflies are Free, 1972.
Melanie Griffith in Something Wild, 1986.
Sarah Jessica Parker opposite Steve Martin in LA Story, 1991.
Drew Barrymore put the "Manic" in Manic Pixie Dream Girl in the 1995 film Mad Love.
Jennifer Aniston (and her ferret) stole Ben Stiller's heart in Along Came Polly.
Kate Winslet in Eternal Sunshine for the Spotless Mind.
Natalie Portman opposite MPDG magnet Zach Braff in Garden State.
Zooey Deschanel in 500 Days of Summer, duh.
Mary Elizabeth Winstead as Ramona Flowers in Scott Pilgrim Vs. The World.
Zoe Kazan as Paul Dano's dream girl (literally) in this year's Ruby Sparks.